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Both have excellent safety profiles with no serious adverse events reported

Side effects About 50% of users reported nausea and one-third reported diarrhea in RANDs survey

Moreover, it promotes the secretion of macrophage colony-stimulating factor (MCSF) and NF-B receptor activator (RANKL), which contribute to bone destruction

Emerging opportunities for nicotinamide N-methyltransferase (NNMT) inhibitor clinical translation. ScienceDirect , 2026

If you already have a deficiency and want to improve your serum zinc levels quickly, it is best to go with zinc picolinate or zinc gluconate