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Possible Effects on Addiction and Reward Pathways Researchers are actively studying GLP-1 medications for their possible role in reducing: Alcohol cravings Nicotine cravings Compulsive shopping Gambling urges Other dopamine-driven behaviors Some patients report reduced interest in alcohol or other compulsive behaviors while on treatment

In healthy individuals GLP-1 and GIP together add up to about 60% of postprandial insulin secretion

Hydrocortisone can restore glycocalyx and improve the 7-day survival rate after brain injury [111]

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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations SAE, sepsis-associated encephalopathy