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Translating Preclinical Data to Human Potential The NHP-to-human pharmacokinetic scaling suggests ASC35 may achieve a 30-day half-life or longer in humans

For comparison, in the table below, we also show those GLP-1 agonists with active ingredients only approved for treatment of diabetes that have less potential for off-label weight loss use (Bydureon BCise, Trulicity)

Total: 2 injections per week with complementary effects

Ethics declarations Ethical approval In this review, ethical approval is not applicable

Beta-3 adrenergic receptor activation appears safe for extended use based on available research

Only a small sample of the 49,000-member myHSteam community shared their GLP-1 experiences, but the results may be interesting to others with HS