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After stimulation, cell culture supernatants were collected, centrifuged at 300 g for 5 min to remove debris, and stored at 80 C until cytokine quantification

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It may be that taking GLP-1 drugs for weight loss is an effective intervention for some employees that will improve health outcomes and reduce costs

Nonetheless, mice deficient for GRP have impaired glucose tolerance, reduced first-phase insulin secretion and impaired GLP-1 secretion in response to an oral glucose challenge [343]

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The compound progressed through Phase 2 trials under multiple sponsors for postoperative ileus and related gastric-motility indications, with one randomized controlled trial published in 2014, but did not advance to a marketed therapeutic in any major jurisdiction