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Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial. Journal of the American Medical Association
A recent metaanalysis of 10 tirzepatide trials ( n = 6836) found a dosedependent relationship for GI AEs, with 5 mg, 10 mg and 15 mg reporting 39% (95% CI: 35%43%), 46% (95% CI: 42%49%) and 49% (95% CI: 38%60%), respectively [24]
Tirzepatides dual GLP-1 and GIP receptor activity translates into enhanced metabolic and weight-loss benefits compared to GLP-1 monotherapy. While semaglutide remains a trusted choice for both diabetes and obesity, these findings suggest tirzepatide may offer an extra edge
Tirzepatide produced greater average weight and waist reduction, while gastrointestinal adverse events were most common with both medications and were generally mild to moderate
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