Tied events were handled using the Exact method 54,55 , if possible, or Efrons method 56 , if not
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Factors influencing symptom severity include: Rate of dose titration (slower escalation reduces symptoms) Meal size and composition (large, high-fat meals exacerbate symptoms) Individual variation in GLP-1 receptor sensitivity Concurrent medications affecting gut motility Patients should be counselled that these effects are pharmacologically expected and usually temporary, but persistent or severe symptoms warrant medical review to exclude complications such as pancreatitis, cholelithiasis, or cholecystitis
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331 In the brain, TMAO is detrimental to neuronal physiology as it induces neuronal senescence, oxidative stress, and alters synaptic plasticity
