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Treatment courses often extend for at least three to six months before meaningful cosmetic changes might be appreciated, and continued application may be required to maintain any gains

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Copper delivery through the skin has many potential applications and thus is widely studied, including the evaluation of the penetration ability of copper peptides 30 , biocompatibility of copper containing IUD 1 , the enhancement of skin absorption through copper-containing nanoparticles 10 and microneedle-mediated delivery 5