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A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects

Moreover, estrogen has positive effects on the viability of skin fibroblasts, and by inducing the expression of transforming growth factor-beta (TGF) and tissue inhibitor of matrix metalloproteinases (TIMPs), and inhibiting matrix metalloproteinases (MMPs), E2 stimulates the production and maintenance of extracellular matrix components, such as collagen type I and III and fibrillin (Lephart and Naftolin, 2021)

Endocrinology 156, 28702882

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Redox signaling mediated by thioredoxin and glutathione systems in the central nervous system

Terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) staining for apoptosis Apoptosis was also determined by the TUNEL assay using an in situ cell death detection kit conjugated with horse-radish peroxidase (POD) (Roche Applied Science, Indianapolis, IN, USA), according to the manufacturer's instructions