Monitoring Parameters : Regularly assess insulin-like growth factor 1 (IGF-1) levels, fasting glucose, lipid profile, and waist circumference to evaluate treatment efficacy and safety
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Some factors believed to lead to hepatocyte injury and inflammation include 3,10,12 : Worsening insulin resistance Imbalanced production of certain endogenous ceramides (while ceramides are important for skin integrity, in other tissues they can disrupt fat metabolism and their accumulation in the liver contributes to hepatocyte damage) (Note that supplemental, plant-derived ceramides, sometimes used to support skin health, differ from endogenous ceramides) Increased levels of oxidized lipids and oxidative stress in hepatocytes Gut microbiome disturbance and disrupted intestinal barrier function Mitochondrial dysfunction Inflammatory immune cell activation Emerging preclinical research also shows degeneration of nerves in the liver occurs in the early stages of NAFLD and becomes more pronounced as the condition progresses
While primarily used for diabetes, they can also aid in weight loss as a secondary benefit
Published 2018 Oct 23
Unlike standard cytoprotective agents that exhibit only prophylactic effectiveness (shared limitation of activity) [41,42,43,44,45,46,47,48], BPC 157 represents a prototype of a more effective class of cytoprotective agents with both prophylactic and therapeutic ability [3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21,22,23,24,27,28,29,30,31,32,34,37,39,40]
