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The primary S source is sulfate, which, following uptake by specific transporters, is reduced and incorporated into the amino acids Cysteine (Cys) and Methionine, and thereafter into proteins and peptides, including the multifunctional tripeptide thiol glutathione (Takahashi et al., 2011)

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Incorporation of a Single His Residue by Rational Design Enables Thiol-Ester Hydrolysis by Human Glutathione Transferase A1-1 Hederos, S., Broo, K.S., Jakobsson, E., Kleywegt, G.J., Mannervik, B., Baltzer, L