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In pathologic conditions, the loss of HS disrupts the charge selectivity of the glomerular filtration barrier, which increases the filtration of proteins and leads to proteinuria (97)
Podrez EA, Poliakov E, Shen Z, Zhang R, Deng Y, Sun M, Finton PJ, Shan L, Gugiu B, Fox PL, Hoff HF, Salomon RG, Hazen SL
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These studies will provide important insights into the how GLP-1R activation in the VTA alters dopamine signaling to influence activity in the two main output pathways of the striatal complex and ultimately decrease cocaine seeking