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doi: 10.1007/s12020-019-02185-4 44 SipponenPMaaroosHI

Fecaliths (hardened stool deposits) form when low-fiber diets cause constipation, potentially blocking the narrow appendix opening and creating conditions for bacterial overgrowth and inflammation

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The trial used a 20-week bi-weekly dose escalation phase followed by a 26-week maintenance phase, for a total of 46 weeks