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Gut barrier dysfunction and gut swelling can affect brain function through multiple mechanisms including passage of swelling mediators across the blood-brain barrier, start of the vagus nerve by gut signals, and alterations in neurotransmitter production by gut bacteria

Apelin exhibits strong metabolic and cardiovascular biology, with failure driven largely by exposure-related hemodynamic effects and lack of signaling bias, suggesting failed pharmacology rather than failed biology

doi: 10.23937/2378-3516/1410098 57 FinneyL

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