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The NICE recommendation was entirely based on the manufacturers application for approval

A recent cohort study found that semaglutide was associated with significant weight loss outcomes compared to placebo, leading to reductions up to 15 percent body weight among those patients taking prescription doses of semaglutide

Once the patent expires, other companies can produce generic versions, which drives down the cost

The timeline for noticing changes depends on several factors, including your starting weight, activity level, and overall health

We have a detailed article on Mounjaro and PCOS covering this in full, but the short version is that PCOS-related menstrual irregularity is often driven by insulin resistance and Mounjaro directly improves insulin sensitivity

In: Frontiers in Endocrinology