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Preclinical studies have demonstrated that inhibition of v-containing integrins effectively attenuates fibrogenesis in models of NASH-related liver fibrosis (173)

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We characterized the BP relying upon the local inhibitor (N3) caught in an active catalysis moment

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Instead, the authors showed that hyperosmotic shock leads to breakdown of sphingomyelin, accumulation of ceramide, and later on to PS exposure and cell shrinkage