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The liver depends on intracellular glutathione for detoxification and that requires the compound to actually reach liver cells intact

Overall risk of bias for each trial was considered low if all domains were at low risk of bias, and high if at least one domain was at high risk of bias

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Transgenic mice that develop thyroid-specific autoantigens in a spontaneous manner have, therefore, been very useful and provide a good platform for studying immunological mechanisms of the disease as reported by Merrill and Pandiyan (2018) (Merrill and Pandiyan 2018)

or (ii) AHI 15 events/h in the absence of clinical symptoms [13]

[Acetaminophen use by chronic alcohol abusers: a therapeutic dose may be too much for the liver]