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Sustainable Results: The effects of semaglutide on weight loss have been shown to be sustainable over time

Implications for Different Patient Responses Clinically, GLP-1R agonists are known for their variability: Some patients lose substantial amounts of weight, while others respond modestly or not at all

Hydration, a protein-rich diet, and micronutrients like vitamin C and zinc assist collagen repair

However, AMPKs effects are context-dependent: under nutrient-replete conditions, AMPK-deficient T cells maintain normal responses, but during glucose restriction or metabolic stress, their adaptability is severely impaired (84)

Similarly, semaglutide ameliorates doxorubicin-induced cardiotoxicity by reducing BNIP3-mediated mitochondrial dysfunction through the PI3K/AKT pathway, enhancing mitochondrial function and reducing cardiac injury (Li et al., 2024), potentiating its clinical application in cardiovascular diseases