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When Diarrhea Starts and How Long It Lasts Most people notice digestive changes within the first 37 days of starting tirzepatide or increasing their dose
Since GLP-1 constipation is caused directly by the medication slowing gastric and intestinal motility, bowel function typically returns to baseline within 1-2 weeks of discontinuation
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Some payor programs discontinue GLP-1s within a set time period
Dosages range from 0.25 mg, 0.5 mg, and 1 mg once weekly for managing type 2 diabetes
On tirzepatide, the same delay produces a sharper dip
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