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In adipose tissue, IR results in aberrant activation of hormone-sensitive lipase (HSL), leading to enhanced lipolysis and increased release of FFAs into the circulation, which are subsequently taken up by the liver (39)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 106.Mazella J., Ptrault O., Lucas G., Deval E., Braud-Dufour S., Gandin C., El-Yacoubi M., Widmann C., Guyon A., Chevet E., et al

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Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas