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Tau has been shown to reduce secondary brain injury after CI by down-regulating the expression of matrix metalloproteinases-3 (MMP-3) in brain-injured rats, thereby protecting the BBB ( Furthermore, investigation revealed that BC and its active constituents, including Tau, TUDCA, and UDCA, can decrease lactate dehydrogenase levels, increase -GT content, raise TEER values, and decrease fluorescein sodium permeability coefficient

Most research examines acute effects over days to weeks, not chronic exposure over months or years

Biomed Pharmacother = Biomed Pharmacother

Accounts of Chemical Research, 1991, 24 9: 264-270

I would say that there are definitely some people who get too much sympathetic stress in response to cold, too much of an adrenaline norepinephrine response and almost like an overtraining response to cold

Many research powders are kept refrigerated or frozen until use