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To examine functional inhibitory projections from the APC to the downstream regions and sIPSCs of MD neurons, recordings were conducted in the presence of CNQX (10 M, Sigma) and patch pipettes were filled with the chloride-based internal solution that contained (in mM): 145 CsCl, 10 EGTA, 10 HEPES, 2 MgCl 2 , 2 CaCl 2 , 2 Mg-ATP, and 5 QX-314

It was a cohort study that examined 18,386 patients with overweight or obesity (mean baseline weight: 242lb) who received tirzepatide or semaglutide between May 2022 and September 2023