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More interestingly, these investigators showed that gemtigliptin in combination with another anti-diabetic compound, but belonging to a different class (biguanides), Metformin (Kim et al., 2018a), exerts a stronger adverse effect on TC cells in vitro

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Cardiometabolic risk factors, including waist circumference, insulin resistance, triglycerides, and inflammatory markers, also improved significantly

In addition, microbial functional profiles characterized by increased representation of LPS biosynthesis and branched-chain amino acid metabolism-pathways previously linked to insulin resistance and low-grade inflammation, have been hypothesized to contribute to reduced metabolic responsiveness

Chen W, Cai W, Hoover B, Kahn CR

McIntyre RS, Kwan ATH, Rosenblat JD, Teopiz KM, Mansur RB