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We performed targeted mass spectrometrybased metabolomics of these plasma samples and discovered that blood plasma levels of the antioxidant GSH were significantly reduced after the first dose of the treatment, and even further decreased after the last dose (Fig

47 There is now significant support to suggest that a subset of these ZF sites do not bind Zn II at all, but instead coordinate either an [2Fe-2S] or a [4Fe-4S] cluster, some of which are redox-active