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In the landmark SELECT trial in 2023, the scope of GLP-1RAs was expanded to assess cardiovascular risk in patients with preexisting cardiovascular disease who were overweight or obese without type 2 diabetes [48]

Diet-induced obesity (DIO) mice were generated by starting a high-fat diet (HFD-60, lipid 60 kcal%, Oriental Yeast) feeding for C57B6J (B6) mice (Oriental Yeast) at six weeks of age

One noteworthy obstacle is the potential need for higher chemotherapy doses in obese patients based on their body weight

But are they right for you

Fernandez Fernandez B, Sarafidis P, Kanbay M et al

We thank Lars Linderoth for providing compound 2 and we thank Henning Thgersen for suggesting pdb entry 1BZ7 as homology model for Fab 3F52