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The variation in nausea rates between different GLP-1 receptor agonists relates to several pharmacological and pharmacokinetic factors

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August 5, 2023: The European Medicines Agency (EMA) and other agencies are currently investigating whether there is a connection between the use of certain diabetes and weight loss drugs, such as Ozempic, Wegovy, and other glucagon-like peptide-1 (GLP-1) receptor agonists, and an increased risk of suicidal thoughts and self-harm

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This approach deviates from the rebate calculation approach set forth in 427.302, which relies on the specified amount defined at 427.20 even when the specified amount and the published payment amount in quarterly pricing files differ

Given the significant TAM of GLP-1 medications, we expect there to be competition, but it could take years for competitors to make any inroads given the time it takes to bring new drugs to market