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24 A recent study of 69 patients with postural orthostatic tachycardia syndrome (POTS)-like symptoms found that 29 (65%) of 44 patients who also reported MCA symptoms had elevations of MC biomarkers (52% histamine in plasma or urine, 36% prostaglandins in plasma or urine, and 9% tryptase), while none of those without symptoms of MCA had elevation of mediators

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