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116 In a placebo-controlled trial in 84 subjects (age 2038 years) with PCOS and overweight or obesity, 1.5 grams of cinnamon daily for eight weeks increased antioxidant status, decreased a measure of oxidative stress, and improved total, LDL-, and HDL-cholesterol levels

Orforglipron is a non-peptide oral GLP-1 medication

Both incorporate glucagon receptor agonism alongside GLP-1 activity, but retatrutide takes this further by adding a third target -- GIP receptor agonism -- making it the first triple-hormone receptor agonist in clinical development

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