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Proinflammatory cytokines TNF- and IL1- activate the canonical NF-B pathway that induce the gene expression of cyclooxigenase-2, inducible nitric oxide synthase-3, inflammatory cytokines, and matrix metalloproteinases [75] These changes lead to the damage of TJs, decreased endothelial integrity and increased permeability at the BBB [73, 76], and to neuroinflammation and the development of chronic neurodegenerative diseases such as AD [10, 77]
MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial
Digestive efficiency, gut health and individual metabolism all influence oral bioavailability
10.3389/fnmol.2017.00377 142
Increased Awareness of Health Issues and Wellness: Consumers are becoming more enlightened and interested in health and wellness issues, significantly increasing the demand for antioxidant-based supplements
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