10.1002/pmic.201800311 22 ForresterS
Consequently, PCOS patients frequently exhibit elevated serum iron, ferritin, and transferrin saturation, indicative of a systemic iron-overloaded state ( Iron deficiency, in turn, disrupts glucose homeostasis and promotes IR, thereby forming a vicious cycle with the metabolic disturbances characteristic of PCOS ( 3.2 Ovarian granulosa cell ferroptosis and impaired follicular development Granulosa cells are the primary site of ovarian hormone synthesis and play a crucial role in regulating follicular development, oocyte maturation, and ovulation through hormone secretion
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Remarkable response to olaparib in a patient with combined hepatocellular-cholangiocarcinoma harboring a biallelic BRCA2 mutation
Together with our findings, these results suggest that -syn aggregation is regulated by phase separation with different interacting proteins and RNAs and is dependent on stress and intracellular conditions
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