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The analysis of the optimized structures of the MichaelisMenten complex indicate that the polar residues at position 13 (Cys or Ser) stabilize the deprotonated GS , which in turn acts as the catalytic Brnsted base and abstracts the proton at position C2 of substrate 7 (Extended Data Fig

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For the major joints, such as the elbow, shoulder, hip, and knee, these procedures can mean the difference between disability and an active life

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