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Approaches used to estimate bioavailability when deriving dietary reference values for iron and zinc in adults

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At the epidemiological observation level, prospective cohort studies have confirmed the predictive value of baseline metabolite concentrations for subsequent disease progression, with current evidence strength graded as moderate (159)

GLP-1 has a natriuretic effect in the proximal renal tubules, the beneficial effects of GLP-1 and GLP-1RA may be related to the regulation of the RAAS (177)

GSTs can also possess ligandin functions and participate in the intracellular transport of auxins

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