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Uysal N, et al

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Pharmacokinetics of IGF-1 LR3 The extended half-life of IGF-1 LR3 stems from two features: the N-terminal extension physically blocks IGFBP binding, and reduced clearance via the IGFBP-ALS ternary complex slows hepatic filtration

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The changes in erythrocytes can be caused due to several reasons, one of them being OS, and these interactions seem to be interconnected