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Both CSE and NNK, major inflammatory inducers in the smoking process, activated the NF-B pathway, as evidenced by the increased mRNA expression of RELA and its target gene BAX (Fig

This receptor is widely distributed throughout various tissues involved in endocrine and metabolic regulation

Reproduction, Nutrition, Development

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480 However, the precise mechanisms through which these molecules and pathways contribute to ferroptosis, as well as the ways in which ferroptosis exacerbates hypertrophic growth of cardiomyocytes, remain poorly understood and warrant further investigation