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The first is thyroid function which is obviously huge for those with Hashimotos
Removes Hyper-Pigmentation
Persistent synovitis can induce VEGF production, promoting neovascularization and increased vascular permeability (143), which may facilitate the influx of iron into the joint cavity and subchondral bone and recruit additional immune cells, thereby intensifying local oxidative stress and inflammatory cascades (144)
In addition, thyroid hormones are important for myelination of the central nervous system, which mostly occurs before and shortly after birth (64, 65)
doi: 10.1371/journal.pone.0070701
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