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What it does establish is biological plausibility for restoration: putting back what the body has lost is a more conservative pharmacological proposition than overdriving a healthy system

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However, these studies also highlight important challenges in clinical translation, particularly regarding interindividual variability in response and the need for optimized delivery strategies

Mice carrying null mutations of the genes encoding insulin-like growth factor I ( Igf-1 ) and type 1 IGF receptor ( Igf1r )

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Taking the Primary Type Error as 5% (Z = 1.96), the Power of the Test as 80% and the effect size as 0.15 units