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Low ROS levels activate cell survival signaling pathways, such as the unfolded protein response and Nrf2 pathways, whereas high ROS levels activate cell death signaling pathways, such as apoptosis and necroptosis pathways 43

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Under conditions of oxidant attack, GSH is rapidly converted to GSSG, making the elevation of the intracellular GSSG/GSH ratio a widely accepted marker for oxidative stress