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Resveratrol improves endothelial cell markers impaired by plasma incubation from women who subsequently develop preeclampsia

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Standard protocols suggest 8-12 weeks on followed by 4-8 weeks off

Several techniques have been developed for the evaluation of the BBB such as the in vivo brain uptake index (BUI) method (88), in situ brain perfusion (89), cerebral microdialysis technique (90, 91), and cell uptake studies in the in vitro models of the BBB (92)

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Firstly, although we observed that the frequency and magnitude of Ca 2+ oscillation were more pronounced in cells from GCGR-KO mice, the detailed mechanism still needs to be elucidated