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Treatment goals and tolerability are reviewed together.

The FDA has issued warnings against the long-term use of benzodiazepines due to these substantial risks, emphasizing the importance of exploring safer alternatives for chronic sleep problems

doi:10.1098/rsfs.2019.0092

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Opposite to the cytoplasmic reductive shift in C57BL/6J brain with aging driven by decreased pyruvate levels, neurons isolated from a mixed C57BL/6 129 mouse background showed an oxidized total NADPH/NADP + with aging (Ghosh et al., 2014)