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Functions of the pentose phosphate pathway in normal and diseased conditions The Pentose phosphate pathway (PPP) is primarily energy forming, and non mitochondrial with only a cytoplasmic enzymatic presence entrusted to utilizing 6 carbon sugars, and producing in turn 5 carbon sugars for the synthesis of neucleotides, nucleic acids and reducing equivalents in the form of NADPH

Renal interstitial cells, endothelial cells, or immune cells in ADPKD kidneys may also undergo ferroptosis or modulate cyst cell ferroptosis via paracrine signalingtheir roles in amplifying cyst growth or fibrosis remain unaddressed

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