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In TNF-stimulated human chondrocytes [42] or thapsigargin-stimulated rat chondrocytes [35], inhibition of the NF-B pathway resulted in less secretion of pro-inflammatory mediators such as IL-6, CCL2 [42] and TNF [35]

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Investigators noted the relatively substantial placebo-associated weight loss as an important contextual factor when interpreting efficacy

In a scientific review posted ahead of the meeting, FDA scientists reiterated their longstanding concerns

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