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HFD feeding aggravates colitis in Winnie mice, but when these mice were treated with IL-22, the intestinal mucosa produced lower cytokine levels in response to HFD, which increased claudin 1 protein expression, thereby improving tight junction function, and decreasing systemic LPS levels

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During Phase 3 clinical studies, patients lost an average of 10.5% of their body weight after taking Orforglipron for more than 72 weeks

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