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The units injected refer to the actual amount of medication administered with each injection

In addition, it has been proposed that the reduced sensitivity and drug resistance to KIT inhibitors partially result from the hyperactivation of MAPK caused by the loss of SPRED1 a model verified in human melanoma cell lines and in vivo zebrafish model (101), but presently untested in mouse models and patient samples

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More rigorous clinical studies and higher-quality evidence are needed to establish the strength and cause-and-effect relationship of this correlation