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In addition, loss of glutathione peroxidase 4 (GPX4), a central regulator of ferroptosis, leads to hemolytic anemia and increases spleen erythroid progenitor death through receptor-interacting protein 3 (RIP3)-dependent necroptosis signaling 48

It also suppresses GABAergic (inhibitory) signaling through PKC-mediated phosphorylation of GABAA receptors, which shifts the balance toward excitatory transmission and makes it easier for new memories to form

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Drucker, a clinician scientist at Sinai Healths Lunenfeld-Tanenbaum Research Institute and a former member of Habeners MGH research group uncovered more of GLP-1s physiological actions and helped translate GLP-1s therapeutic benefits to drugs