Beyond repurposing existing drugs, Nrf2 activators (e.g., Dimethyl Fumarate) are particularly promising as they upstreamly regulate a network of antioxidant genes, including SLC7A11, GPX4, HO-1, and FTH1, thus simultaneously bolstering defenses against multiple drivers of ferroptosis ( Table 2 ) (176)
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A cross-sectional study of 4500 participants found that serum vitamin C levels of 50.5-67.0 mol/L were associated with reduced liver disease risk whereas serum levels greater than 67 mol/L were associated with a higher risk of MASLD, liver fibrosis and cirrhosis
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