glp 1 and trying to get pregnant Taking GLP-1s before pregnancy may raise complications risk Can Taking a GLP-1 Before

Always consult your GP, prescriber, or thyroid specialist before starting, stopping, or changing any medication

Does NAD+ affect how GLP-1 medications work

Increased insulin secretion and glucose tolerance in mice lacking islet amyloid polypeptide (amylin) Biochem Biophys Res Commun

A separate 2025 trial in NEJM Evidence (Shah et al.) in adults with T1D and obesity on AID found that around one in three semaglutide-treated participants met a combined goal of improved time in range, low hypoglycemia, and at least 5% weight loss

This meant no PAM enzyme, and the mice developed signs of GLP-1 resistance too, with blood sugar left unregulated despite elevated levels of GLP-1

Gallwitz B, Bhmer M, Segiet T, Mlle A, Milek K, Becker B, et al