In a 2017 study using human vascular endothelial cells and a chick chorioallantoic membrane assay, Hsieh and colleagues reported that BPC-157 exposure increased VEGFR2 mRNA and protein expression, promoted VEGFR2 internalization (an effect blocked by the endocytosis inhibitor dynasore), and time-dependently activated the VEGFR2-Akt-eNOS axis without a corresponding increase in VEGF-A (Hsieh et al., 2017)
Mutations in the MRP2 gene are associated with DubinJohnson syndrome, a condition due to the lack of hepatobiliary transport of organic anions without bile salts resulting in conjugated hyperbilirubinemia [81,82]
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& Majerus, P
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