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Further research is needed to explore therapeutic strategies targeting the KP to mitigate depressive symptoms and cognitive impairments associated with these conditions

Gold: The Holistic Snapshot This is a very popular choice because it looks at the cofactors that help the thyroid work

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Endoplasmic reticulum stress The endoplasmic reticulum (ER) regulates various cellular pathways, including protein synthesis and quality control, calcium storage and release, and lipid biosynthesis [95, 96]

Acknowledgements We acknowledge the support of the staff of the Pennsylvania State University College of Medicine Clinical Research Center and Investigational Pharmacy

Treatment depends on the cause and severity: dietary deficiency may be treated with oral B12 supplements, while pernicious anaemia or neurological symptoms typically require intramuscular hydroxocobalamin injections