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As a weight loss doctor at the New Jersey Bariatric Center a common question from patients is which medication offers the most weight loss

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While body fat is certainly being lost, a considerable portion of early weight loss often comes from fluid shifts inside the body

Overall, both medications offer new hope in the domain of weight and glucose management, signaling a shift towards more integrated therapeutic strategies

Some individuals notice early shifts in appetite control or energy levels within the first week, while others begin seeing clearer changes closer to four to six weeks

Now data from a new study in mice performed by scientists at the University of Virginia shows that this emerging class of weight-loss drugs suppress hedonic eating by modulating a reward circuit deep in the brain that is separate from previously described mechanisms that broadly affect appetite