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SIRT1-autophag y axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1 and IL-18

This process involves reducing the number of metal transporters at the plasma membrane

doi: 10.1016/j.foodchem.2018.07.141 42

Wever et al., 1997

It confirmed ferroptosis as the core mechanism in PD pathogenesis synergistically induced by iron overload and inflammation, which activate ferroptosis by disrupting iron metabolism, inhibiting the antioxidant system and exacerbating lipid peroxidation, further causing dopaminergic neuronal damage, -syn aggregation, and PD-characteristic motor/cognitive impairments (186).Treating SH-SY5Y dopamine neurons with rotenone and using RhoNox-1 staining, followed by confocal microscopy observation and flow cytometry analysis, revealed significantly higher intracellular Fe 2+ in the rotenone group, confirming cellular iron overload (187)

Athletic performance: Reduces muscle fatigue while increasing recovery and stamina