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The additional glucagon receptor activation increases energy expenditure and stimulates hepatic fat oxidation, which in clinical trials led to significantly greater weight reduction than comparable agents

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Antibodies against TPO and TSH receptor were absent, and the inflammatory markers CRP, ESR and white blood count were elevated

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Let us translate the clinical data into concrete monthly expectations, drawn primarily from the STEP 1 trial, which remains the landmark study for semaglutide 2.4 mg in weight management